Born in Pylos, Greece, Spyropoulos studied at the Athens School of Fine Arts initially and then continued his studies in Paris. His career was full of solo and group exhibitions in Greece and major art centers in the world, culminating in the UNESCO Prize at the Venice Biennale in 1960. At the top of his international recognition, he founded with his wife the Yannis and Zoe Spyropoulos Foundation.
Setting off from Expressionism and Fauvism, he found a path towards Abstraction by reducing to a minimum the color palette. His paintings consist of fictional images, reminiscent of cosmogony, where traces of colour jump out of dark surfaces. Spyropoulos never ceased to have «conversations» with himself and with nature in a constant pursuit of natural harmony.